Обнаружение chlamydia trachomatis, вирусов герпеса, trichomonas vaginalis как кофакторов вируса папилломы человека, индуцирующих воспаление и морфологическую трансформацию клеток при фоновых и предраковых заболеваниях женских половых органов

Abstract

The complex cytological, microbiological, and molecular-biological analysis of urethra and cervix smears-scrapings from 118 women with background (cervicitis, cervical erosion) and precancerous (cervical dysplasia I and II degree) diseases was carried out. It was shown that in addition to HPV HCR, lymphoid infiltration, and detection of hypertrophied atypical cells often such pathogens as C. trachomatis, viruses of the family Herpesviridae, T. vaginalis were detected in the samples. Following the etiopathogenetic treatment symptoms of the inflammatory process both in the urethra and cervix decreased, in parallel a reduction of hypertrophic and morphological changes of cells, epithelization of cervical erosion was occurred. The important role of human papillomavirus infection in addition to other pathogens (C. trachomatis, viruses of the family Herpesviridae, T. vaginalis) as an inflammation cofactor and morphological transformation cell triggers was inferred.